<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 24

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184IV N348NI K103S, G190A   K20R, E28EG, V35T, E36A, T39E, S48T, K122E, D123N, Q174K, T200A, R211K, F214L, V245Q, E248D, A272P, K275R, K277R, Q278H, E291D, V292I, I293V, P294T, I329L, Q334H, G335D, R356K, G359T, T377L, K390R, E396DN, T397I, A400T, E404D, E449D, R461K, V466I, S468A, T470N, D471E, T477A, H483Q, L491P, E514D, L517I, S519T, K527T, K530R, A534S, A554S W153W*
>19ZA.24| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTGEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQG*KGSPAIFQSSMTKILEPFRKKNPDIVI
YQYVDDLYVASDLEIGQHRAKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVRHLCKLLRGTKALTDIVTLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGHDQWTYQIYQEPFKILKTGKYAKMRTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKNIWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRDTKLGKAGYVTDKGRQKIVALNETTNQKAELQ
AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSDSEIVTQIIEQLITKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012