<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP 36

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V N348NI V106A F227FL V35T, E36A, T39E, S48T, V60I, K122E, K173A, Q174K, I178L, G196E, T200A, E203K, Q207E, V245Q, A272P, E291D, V292I, I293V, Q334D, G335D, R356K, M357R, G359T, A376S, T377L, T386I, K390R, A400I, E404D, V435A, G436E, L452I, V466I, S468T, L469I, T470S, D471E, H483Q, L491P, S519N, K527Q, K530R, A534S, A554S W410W*
>18ZA.36| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPDLVI
YQYVDDLYVGSDLEIEQHRAKIKELREHLLRWGFTTPDKKHQKEPPLLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKILKTGKYAKRRTA
HTNDVKQLTEAVQKISLESIVIWGKIPKFRLPIQKETWEIWWTDYWQAT*IPEWEFVNTP
PLVKLWYQLEKEPIAEAETFYVDGAANRETKIGKAGYVTDRGRQKIVTISETTNQKTELQ
AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIQKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012