<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP 60

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184MIV N348NI Y181C   I31IL, V35T, E36A, T39E, K122E, D123N, K173T, Q174K, D177E, T200A, Q207E, V245N, A272P, E291D, V292I, I293V, D324E, Q334E, G335D, R356K, M357R, G359T, K366R, A376S, T377M, K385R, K390R, T403I, E404D, I434L, V435A, A437V, L452I, V467I, S468T, L469I, T470N, D471E, H483Q, L491S, S519N, K530R, A534S, A554S  
>12ZA.60| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKLKALTAICEEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI
CQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPINLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGEDQWTYQIYQEPFKILKTGKYAKRRTA
HTNDVRQLTEAVQKISMESIVIWGRTPKFRLPIQKETWEAWWIDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPLAGVETFYVDGAANRETKIGKAGYVTDRGRQKVITINETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Brehm, JH Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors. Clin Infect Dis, 2012