<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5195 CA21312 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 NRTI 208
2 SQV+ RTV+ DDC 73
3 NVP+ NFV+ D4T 130
4 SQV+ RTV+ D4T+ 3TC 62

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48EV, V82F, L90LM K43T L10I, I13V, I15V, E34EK, E35D, M36I, N37S, I54X, D60DE, I62V, L63T, I64V, I72V, V77VI  
>CA21312| codons 1-99
PQITLWQRPIVTVKVGGQLKEALLDTGADDTVLKDISLPGRWTPKLIEGIGGFXKVRQYE
QVTVEICGHKAVGTVLIGPTPFNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219KR   F227FL K20R, V35L, T39AS, K43KE, E44D, V118I, K122E, E203K, Q207E, H208FY, R211K, K223E, K277R, Q278H, R284K, A288S, I293V  
>CA21092| codons 1-300
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIKELREFLWKWGFYTPDRKHQEEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLKGTKSLTEVVPLTEEAE

References
Author Title Citation
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005