Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4420 | CA21303 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | 65 |
| 2 | D4T+ 3TC+ NFV | 47 |
| 3 | ADV+ NVP+ IDV | 13 |
| 4 | ADV+ ABC+ IDV+ NVP | 30 |
| 5 | NVP+ IDV+ ABC | 25 |
| 6 | ABC+ IDV+ RTV | 8 |
| 7 | ABC+ APV+ RTV+ D4T | 52 |
| 8 | 3TC+ D4T+ ABC+ LPV | 24 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | Q58E, G73S, L89V | L10I, I13V, I15IV, K20T, M36I, I62IV, L63P, H69Y, A71V, I72E, V77I, V82I, I93L |
| >CA21303| codons 1-99 PQITLWQRPIVTVKVGGQLTEALLDTGADDTILEEINLPGRWKPKIVGGIGGFMKVREYD QVPIEICGYKVESTVLIGPTPINIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | F77FL | E28K, K43E, E44A, K104R, V118I, K122E, G196E, E203V, Q207E, H208Y, R211K, R284K, I293V, E297A |
| >CA21075| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKLMDLRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIVELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVPLTAEAE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |