Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6800 | CA21302 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 170 |
| 2 | AZT+DDI | 56 |
| 3 | 3TC+AZT | 22 |
| 4 | 3TC+AZT+SQV | 4 |
| 5 | 3TC+AZT+RTV | 65 |
| 6 | D4T+DDI+NVP | 39 |
| 7 | DDC+RTV+SQV | 39 |
| 8 | 3TC+ABC+EFV+RTV+SQV | 17 |
| 9 | APV+D4T+DDI | 44 |
| 10 | 3TC+ABC+IDV+RTV | 39 |
| 11 | ABC+DDI+LPV | 9 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I84V | L33F, N83D | T4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89I |
| >CA21302| codons 1-99 PQIPLWQRPVVTIKIGGQLREALLDTGADDTVFENITLPGRWKPKLIGGIGGIIKVKQYD QVPIEICGHKAIGAVLVGPTPVDVVGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, Y115F, Q151M, M184V, T215F | A62V, V75I, K219Q | K103N, Y188L | K20R, I31R, T39A, A98S, V118I, K122E, R172K, V179I, I202V, F214L, L228H, V245VE, T286A, V292I |
| >CA21086| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKRKALVEICAELEKEGKISKIGPENPYNTPV FVIKKKNSDKWRKLIDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAFFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDIII YQYVDDLLVGSDLEIGQHRTKVEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |