Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8355 | CA21281 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | D4T+ 3TC+ RTV | 52 |
| 3 | AZT+ DDI+ IDV | 52 |
| 4 | RTV+ SQV+ 3TC+ D4T | 104 |
| 5 | ABC+ EFV+ RTV+ SQV | 52 |
| 6 | APV+ SQV+ EFV+ ABC | 56 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, L90M | L23I, L33I, F53L, G73C | L10I, E35D, M36I, I62V, L63P, I64V, I66L, A71X, I72MV, I93L |
| >CA21281| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTIIEDINLPGRWKPKIVGGIGGLVKVRQYD QVPVELCGHKXMCTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69DN, L74V, M184V, L210W, T215Y | K219R | Y181C, G190A | K101H, V108VI | E40F, K43E, V118I, K122E, I135IT, S162C, V179I, T200A, E203K, Q207D, H208Y, R211K, K223Q, L228R, Q242L, A272P, P294S |
| >CA21063| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII CQYVDDLYVASDLEIGQHRAKIKELRDYLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT VLPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVISLTEEAE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |