Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2190 | CA21274 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 130 |
| 2 | D4T+3TC | 34 |
| 3 | D4T+3TC+IDV | 43 |
| 4 | None | 44 |
| 5 | D4T+3TC+NFV | 8 |
| 6 | D4T+EFV+RTV+SQV | 109 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L23LI | L10I, F53Y, L63P, I72V, V77I, L89T, I93L |
| >CA21274| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMNLPGRWKPKIIGGIGGYIKVRQYD QIPIEICGHKAVGTVLIGPTPVNIIGRNTMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | K219Q | K103N | P225H | K102R, V118I, F214L, L228R, P243H, V245EK |
| >CA21055| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDQKHQKEHPFRWMGYELHPDKWT VQHIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |