Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5939 | CA21254 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | NA |
| 2 | D4T+RTV+SQV | 47 |
| 3 | ABC+DDI+EFV+NFV | 49 |
| 4 | ABC+D4T+EFV+3TC | 50 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10I, K20R, E35D, M36I, N37E, R41K, I62V, L63P, A71T, I93L |
| >CA21254| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGKWKPKLIGGIGGFVKVRQYD QVPIEICGHKTIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | K219N | K101DE, Y181C, G190S | T39A, Q174QR, T200A, E204EK, H208HY, R211RK, D237E, A272P, V292VI, I293V, E297A | V276VA, L282L* |
| >CA21036| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI CQYMDDLYVSSDLEIGQHRAKIEKLRQYLWKWGFYTPDNKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKAKQLCK*LRGTKALTEIVPLTAEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |