Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5075 | CA21239 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 91 |
| 2 | AZT+DDC | 61 |
| 3 | 3TC+AZT | 26 |
| 4 | 3TC+D4T+NVP | 13 |
| 5 | 3TC+NFV+NVP | 74 |
| 6 | 3TC+AZT+NFV+NVP | 112 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | Y188L | K43KQ, E44D, K64R, K102E, V111I, K166R, V189I, G196GE, H208Y, R211K, K223KQ, V245E, T296S, E297K |
| >CA21239| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIRKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKEKKSVTVLDIGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLLIGSDLEIEQHRTKIEELRQYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLSKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10V, I13V, K20T, E35DN, M36I, N37S, R57K, I62V, L63P, I64V, T74S, I93L |
| >CA21456| codons 1-99 PQITLWQRPVVTVKIGGQLTEALLDTGADDTVLEDISLPGRWKPKMIGGIGGFIKVKQYD QVPVEICGHKAIGSVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |