Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5981 | CA21236 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | 3TC+AZT | 109 |
| 3 | 3TC+AZT+RTV | 74 |
| 4 | DDI+DLV+NFV | 17 |
| 5 | D4T+DLV+RTV+SQV | 65 |
| 6 | ABC+APV+DDI | 52 |
| 7 | ABC+APV+D4T+RTV | 51 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LV, L210W, T215Y | K219N | K103N, Y181C, G190A | K20R, T39A, E40X, K43E, E44EA, V118VI, K122P, R172RK, Q174R, E203K, Q207E, H208Y, R211K, K223T, L228H |
| >CA21236| codons 1-260 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAXLEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKRNPDIVI CQYMDDLYVASDLEIGQHRTKIKELREYLWKWGFYTPDNKHQTEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54IM, I84V, L90M | L33F | L10I, K20R, E35D, M36I, N37S, R41K, I62V, L63P, A71V, P79AS |
| >CA21453| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVFEDISLPGKWKPKLIGGIGGFMKVRQYD QVPIEICGHKVIGTVLVGATPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |