Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1498 | CA21156 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T | 61 |
| 2 | AZT | 44 |
| 3 | 3TC+AZT+SQV | 82 |
| 4 | 3TC+AZT | 6 |
| 5 | 3TC+AZT+IDV | 42 |
| 6 | D4T+NFV+NVP | 38 |
| 7 | 3TC+DDI+SQV | 102 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67DN, L74LV, M184V, L210W, T215Y | K219E | Y181C | E28A, K122E, S162C, E169D, Q197E, Q207E, R211K, A272P, K277R, T286A, A288AS, E297T |
| >CA21156| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDIVI CQYVDDLYVGSDLEIGEHRTKIEELREHLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKSLTEVIPLTTEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, L90M | L23LI, G73S | L10I, I13V, I62IV, L63P, A71V, I72L, V77I |
| >CA21374| codons 1-99 PQITLWQRPIVTVKIGGQLKEAILDTGADDTVLEEMNLPGRWKPKMIGGIGGFLKVRQYD QVPIEICGHKVLSTVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |