Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA799 | CA21123 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 261 |
| 2 | DDI | 65 |
| 3 | AZT+DDI | 52 |
| 4 | 3TC+AZT | 48 |
| 5 | D4T+DDC+RTV | 31 |
| 6 | D4T+DDC+IDV | 13 |
| 7 | 3TC+AZT+RTV+SQV | 13 |
| 8 | D4T+NFV+NVP | 9 |
| 9 | 3TC+AZT+D4T+IDV | 14 |
| 10 | 3TC+AZT+DDI+RTV+SQV | 27 |
| 11 | 3TC+AZT+IDV+RTV | 8 |
| 12 | 3TC+ABC+AZT+Unknown | 39 |
| 13 | ABC+LPV+TDF | 53 |
| 14 | ABC+APV+LPV+TDF | 42 |
| 15 | None | 13 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | D67E | K103KNRS, Y181I | A98G | S3C, V35M, K43Q, E44D, S68G, K122E, I135T, Q174QK, D177E, V179I, G196E, E203K, Q207E, R211RK, H221Y, V245VM, D250DE, A267X | N136NI |
| >CA21123| codons 1-271 PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV FAIKKKEGTKWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKSKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTINETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPEIII IQYVDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIMLPEKESWTVNDIQKLVGKLNWXSQIY |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33F, G73S, L89LV | L10I, I15V, K20V, L24F, E35DN, M36I, R57K, I62V, L63P, A71V, I72M |
| >CA21348| codons 1-99 PQITLWQRPIVTIKVGGQLVEALFDTGADDTVFEDINLPGRWKPKMIGGIGGFVKVKQYD QVPIEICGHKVMSTVLVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |