Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8381 | CA21110 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 208 |
| 2 | 3TC+ D4T | 104 |
| 3 | 3TC+ D4T+ RTV | 8 |
| 4 | 3TC+ D4T+ SQV | 104 |
| 5 | APV+ 3TC+ NVP | 156 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, L74I, M184V, L210W, T215F | K219Q | Y181C, G190A | T39E, V60I, K122E, I135T, V179I, H208Y, R211K, D218E, L228H, V245T, A272P, E297K |
| >CA21110| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, L90M | L10F | I13V, K20I, M36MI, I64V, T74S, V77I, I85IV |
| >CA21328| codons 1-99 PQITLWQRPFVTVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIVGGIGGFMKVRQYD QILVEICGHKAIGSVLIGPTPVNIVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |