<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA8371 CA21098 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T+NFV+SQV 52
2 3TC+AZT+IDV 93

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y       K20R, V35M, T39A, K43E, V90I, V111I, I135T, S162Y, E203D, H208F, R211K, A272P, K277R, T286A, E297K  
>CA21098| codons 1-300
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDIGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIDELRQFLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M L33LI L10I, I13V, Q18H, E35D, M36I, N37D, I62V, L63P, A71T, I72V, P79A  
>CA21316| codons 1-99
PQITLWQRPIVTVKIGGHLKEALLDTGADDTVIEDIDLPGRWKPKIIGGIGGFIKVRQYD
QVPIEICGHKTVGTVLVGATPVNVIGRNLMTQIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005