Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8369 | CA21096 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 74 |
| 2 | DDC | 78 |
| 3 | 3TC+AZT | 35 |
| 4 | 3TC+AZT+IDV | 232 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, M184V | D67G, K219Q | K20R, A33G, V118I, K122E, I135T, Q197P, T200A, F214L, T286P, I293V, E297A |
| >CA21096| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKGLVEICTEMEKEGKISKIGPENPYNTPV FAIKKKGSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGPHRAKIEELRQHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGPKALTEVVPLTAEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A, L90M | G73T | L10I, T12P, L19V, K45R, I62V, L63P, C67L, H69Q |
| >CA21314| codons 1-99 PQITLWQRPIVPIKIGGQVKEALLDTGADDTVLEEMNLPGRWKPRMIGGIGGFIKVRQYD QVPIEILGQKAITTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | Genotypic predictors of human immunodeficiency virus type 1 drug resistance. | PNAS, 2006 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |