Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5149 | CA21090 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 217 |
| 2 | AZT+DDC | 39 |
| 3 | 3TC+AZT | 17 |
| 4 | 3TC+DDC | 47 |
| 5 | 3TC+AZT+IDV | 56 |
| 6 | D4T+DDI+NFV+SQV | 35 |
| 7 | D4T+DDI+RTV+SQV | 34 |
| 8 | 3TC+ABC+EFV | 71 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | F227L | T39A, K43Q, E44D, T58S, A98S, V106G, V118I, K122E, D123S, S162C, E203K, R211K, K223Q, L228R, D237DN, I293V |
| >CA21090| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNSPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSGTVLDVGDAYFSIPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELRQHLWKWGFYTPDKKHQQEPPLRWMGYELHPNKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73GC | L10I, Q18R, L19V, K20I, L63P, I64V, I72V, P79D, I93L |
| >CA21308| codons 1-99 PQITLWQRPIVTIKIGGRVIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKAVCTVLVGDTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |