<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB3-P20 P20-70 U.S. 1998 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 RTI 52
2 IDV+RTI 70

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, V82T   L10R, R57K, L63P, A71V, V77I, I93L  
>P20-70| E06 | codons 1-99 | clone E06
PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD
QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P20-70| E07 | codons 1-99 | clone E07
PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD
QIPIEICGHKVIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P20-70| E09 | codons 1-99 | clone E09
PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD
QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P20-70| E02 | codons 1-99 | clone E02
PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD
QIPIEICGHKVIGTVLIGPTPTNIIGRNLMTQLGCTLNF
>P20-70| E11 | codons 1-99 | clone E11
PQITLWQRPCVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD
QIPIEICGHKVIGTVLIGPTPTNIIGRNLLTQLGCTLNF
>P20-70| codons 1-99
PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD
QIPIEICGHKVIGTVLIGPTPTNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    G190S   S162C, Q207E, R211K  
>P20-70| E06 | codons 1-229 | clone E06
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAILQCSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIKELREHLLKWGFTTPDKKHQKEPPFLW
>P20-70| E07 | codons 1-229 | clone E07
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DNDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTEILGPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW
>P20-70| E09 | codons 1-229 | clone E09
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKGGKISKIGPGNPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIKELREHLLKWGFTTPDKKHQKEPPFLW
>P20-70| E02 | codons 1-229 | clone E02
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPLGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKGPPFLW
>P20-70| E11 | codons 1-229 | clone E11
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKVSKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW
>P20-70| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVSSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005