Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P20 | P20-58 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | RTI | 52 |
| 2 | IDV+RTI | 58 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82T | L10R, R57K, L63P, A71V, V77I, I93L |
| >P20-58| F04 | codons 1-99 | clone F04 PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD QIPIEICGHKVIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P20-58| codons 1-99 PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD QIPIEICGHKVIGTVLIGPTPTNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| F87X, K103E, I135L, S162C, V179A, Q207E, R211K |
| >P20-58| F04 | codons 1-229 | clone F04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDXWEVQLGIPHPAGLKKEKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIAI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P20-58| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDXWEVQLGIPHPAGLKKEKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIAI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |