Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P20 | P20-24 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | RTI | 52 |
| 2 | IDV+RTI | 24 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82T | L10R, R57K, L63P, V77I, I93L |
| >P20-24| G10 | codons 1-99 | clone G10 PQITLWQRPRVTIKIGGQLKEALLDTGADGTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD QIPIEICGHKTIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P20-24| G04 | codons 1-99 | clone G04 PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD QIPIEICGHKVIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P20-24| G12 | codons 1-99 | clone G12 PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P20-24| G02 | codons 1-99 | clone G02 PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P20-24| G06 | codons 1-99 | clone G06 PQITLWQRPRVTIKIGG*LKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKAIGTVLIGPTPTNIIGRSLLTQLGCTLNF >P20-24| G01 | codons 1-99 | clone G01 PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPRMIGGIGGFIKVKQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P20-24| G07 | codons 1-99 | clone G07 PQITLWQRPRVTIKIGEQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P20-24| codons 1-99 PQITLWQRPRVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVKQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| S162C, Q207E, R211K |
| >P20-24| G10 | codons 1-229 | clone G10 PISPIETVPVKLKPGMDGPKVKQWPLAEEKVKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCGMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P20-24| G04 | codons 1-229 | clone G04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGSKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII YQYTDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPGKKHQKEPPFLW >P20-24| G12 | codons 1-229 | clone G12 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P20-24| G02 | codons 1-229 | clone G02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P20-24| G06 | codons 1-229 | clone G06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P20-24| G01 | codons 1-229 | clone G01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFKKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P20-24| G07 | codons 1-229 | clone G07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPRIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW >P20-24| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLW |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |