Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PRRT_4178 | PRRT_4178 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, T12P, N37S, R41K, L63V, G68GE, L89M, I93L | W42W*, G51GE, R87RK |
| >PRRT_4178| codons 1-99 PQITLWQRPVVPIKIGGQLKEALLDTGADDTVLEEMSLPGK*KPKMIGGIEGFIKVRQYD QIVIEICEHKAIGTVLVGPTPVNIIGKNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| E6EK, V60I, K102KR, D123E, I135T, I180V, D192DN, Q207A, R211K, V245K, A272P, K277R, I293V, E297T, S322T, Q334H, F346Y, M357IT, E404D, E449ED, S468P, L517V, Q547K, A554S | G262GE, E305EK |
| >PRRT_4178| codons 1-560 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVV YQYMDDLYVGSNLEIGQHRTKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVEKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTTEAE LELAKNREILKEPVHGVYYDPTKDLIAEIQKQGHGQWTYQIYQEPYKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEAWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRDTKLGKAGYVTDRGRQKVVPLTDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDKSESEVVSQIIEQLIKKEKVYLAWVPAHK GIGGNEKVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Brumme, ZL | HLA-associated immune escape pathways in HIV-1 subtype B gag, pol and nef proteins. | PLoS Med, 2009 |