<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MNR22 MNRSEN France 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDC 51
2 IDV+ DDI+ AZT 8
3 AZT+ NFV+ 3TC 8
4 D4T+ NVP+ SQV+ RTV 60
5 APV+ D4T+ DDI 25
6 NFV+ SQV+ EFV+ ABC+ DDI 5

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, V82A, I84V, L90M G73S L10I, K55R, Q61E, I62V, L63P, C67F, A71V  
>MNRSEN| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIRVRQYD
EVPIEIFGHKVISTVLVGPTPANVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, V75T, T215Y K219Q K101E, Y181C, G190A   K32Q, E44D, K102Q, V118I, K122E, L210S, D218E, D237G W229G, M230W, Y232S, K238G
>MNRSEN| codons 1-238
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALVEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTRWRKITDFRELNKRTQDFWEVQLGIPHPAGLEQKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVASDLEIGQHRTKIEELRQHLSRWGFYTPEQKHQKEPPFLGWGSELHPGG

References
Author Title Citation
Rousseau, MN Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. JAIDS, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005