Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR22 | MNRSEN | France | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 51 |
| 2 | IDV+ DDI+ AZT | 8 |
| 3 | AZT+ NFV+ 3TC | 8 |
| 4 | D4T+ NVP+ SQV+ RTV | 60 |
| 5 | APV+ D4T+ DDI | 25 |
| 6 | NFV+ SQV+ EFV+ ABC+ DDI | 5 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, T215Y | K219Q | K101E, Y181C, G190A | K32Q, E44D, K102Q, V118I, K122E, L210S, D218E, D237G, K238G | W229G, M230W, Y232S |
| >MNRSEN| codons 1-238 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKITDFRELNKRTQDFWEVQLGIPHPAGLEQKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELRQHLSRWGFYTPEQKHQKEPPFLGWGSELHPGG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A, I84V, L90M | G73S | L10I, K55R, Q61E, I62V, L63P, C67F, A71V |
| >MNRSEN| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIRVRQYD EVPIEIFGHKVISTVLVGPTPANVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |