Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR20 | MNRBRI | France | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 150 |
| 2 | AZT+ DDI | 50 |
| 3 | DDC+ 3TC+ IDV | 12 |
| 4 | 3TC+ DDI+ NFV | 28 |
| 5 | D4T+ 3TC+ DDI | 20 |
| 6 | AZT+ 3TC+ NVP+ SQV+ RTV | 9 |
| 7 | DDI+ NVP+ RTV+ SQV | 14 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215F | D67S, V75A, K219E | K20R, T39A, T69N, K101Q, I135M, S162N, D177E, I178M, V179I, D218E, T240A | V241D |
| >MNRBRI| codons 1-241 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKSSNRWRKIADFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPEMII YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPEEKHQKEPPFLWMGYELHPDKWA D |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, T12S, K14R, L19T, R57K, I62V, L63P, A71V, I93L |
| >MNRBRI| codons 1-99 PQITLWQRPIVSIRIGGQTKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVKQYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |