<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MNR20 MNRBRI France 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 150
2 AZT+ DDI 50
3 DDC+ 3TC+ IDV 12
4 3TC+ DDI+ NFV 28
5 D4T+ 3TC+ DDI 20
6 AZT+ 3TC+ NVP+ SQV+ RTV 9
7 DDI+ NVP+ RTV+ SQV 14

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L74I, M184V, T215F D67S, V75A, K219E     K20R, T39A, T69N, K101Q, I135M, S162N, D177E, I178M, V179I, D218E, T240A V241D
>MNRBRI| codons 1-241
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKSSNRWRKIADFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPEMII
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPEEKHQKEPPFLWMGYELHPDKWA
D

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M   L10I, T12S, K14R, L19T, R57K, I62V, L63P, A71V, I93L  
>MNRBRI| codons 1-99
PQITLWQRPIVSIRIGGQTKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVKQYD
QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Rousseau, MN Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. JAIDS, 2000
Gonzales, MJ Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. AIDS, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005