Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR19 | MNR718ryn | France | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 20 |
| 2 | AZT+ DDI | 66 |
| 3 | DDI+ 3TC+ IDV | 13 |
| 4 | 3TC+ D4T+ NFV | 25 |
| 5 | ABC+ NVP+ RTV+ SQV | 9 |
| 6 | DDI+ D4T+ SQV+ RTV | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10I, I15V, K20T, I62V, L63P, A71V, V77I, I93L |
| >MNR718ryn| codons 1-99 PQITLWQRPIVTIKVGGQLTEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | Y181C | A98G | K20R, V35M, K43Q, E44D, V111I, V118I, K122E, M164I, E169D, V179I, G196E, T200R, E203V, Q207E, H208Y, R211K, H221Y, K277R, I293V, E297K, D324E, G333E, Q334P, R356K, G359S, K366R, A371V, V435M |
| >MNR718ryn| codons 1-435 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSITKILDPFRKQNPDIII CQYMDDLYVGSDLEIEQHRRKIVELREYLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQEPGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVRQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIM |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |