<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MNR19 MNR718ryn France 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 20
2 AZT+ DDI 66
3 DDI+ 3TC+ IDV 13
4 3TC+ D4T+ NFV 25
5 ABC+ NVP+ RTV+ SQV 9
6 DDI+ D4T+ SQV+ RTV 34

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M G73S L10I, I15V, K20T, I62V, L63P, A71V, V77I, I93L  
>MNR718ryn| codons 1-99
PQITLWQRPIVTIKVGGQLTEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD
QVPIEICGHKVISTVLIGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y   Y181C A98G K20R, V35M, K43Q, E44D, V111I, V118I, K122E, M164I, E169D, V179I, G196E, T200R, E203V, Q207E, H208Y, R211K, H221Y, K277R, I293V, E297K, D324E, G333E, Q334P, R356K, G359S, K366R, A371V, V435M  
>MNR718ryn| codons 1-435
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDIGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSITKILDPFRKQNPDIII
CQYMDDLYVGSDLEIEQHRRKIVELREYLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQEPGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVRQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIM

References
Author Title Citation
Rousseau, MN Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. JAIDS, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005