Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR18 | MNRMP1263 | France | 1999 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 35 |
| 2 | 3TC+ D4T | 39 |
| 3 | DDI+ D4T+ SQV | 56 |
| 4 | D4T+ NFV+ SQV | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73S | L10I, L19T, K20R, E35D, M36I, N37D, I62V, L63P, H69Y, A71T, I72T |
| >MNRMP1263| codons 1-99 PQITLWQRPIVTIKIGGQTREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGYKTTSTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V35T, T39D, K49R, V60I, V118I, K122E, I135T, E169D, D177E, G196E, I202V, Q207E, R211K, V245N, D250E, A272P, K277R, T286A, I293V, E297R, G335D, R356K, G359S, T377M, T386I, K390R, A400T, E404D, V435I |
| >MNRMP1263| codons 1-440 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICDELEKEGKISRIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKVEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPINLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIAMESIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETF |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |