<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MNR16 MNRMP1305 France 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 100
2 AZT+ DDC 27
3 3TC+ AZT 30
4 AZT+ 3TC+ RTV+ SQV 23
5 AZT+ NFV+ SQV 20
6 ABC+ EFV+ NFV 18
7 ABC+ NFV 26

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69S_SV, T215Y A62V Y188L   D123E, S162Y, D177E, V179I, T200A, Q207E, L228H, V245E, A272P, E297K, A371V, A400I, V435I, D460N, L491S, S519N  
>MNRMP1305| codons 1-548
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FVIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIII
YQYMDDLLVGSDLEIGQHRAKIEELREHLLRWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEIWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSLTDTTNQKTELQ
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQV

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90M   L19I, N37E, L63P, C67Y, H69N, A71V, V77I, Q92K, I93M  
>MNRMP1305| codons 1-99
PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEMELPGRWKPKMIGGIGGFIKVRQYD
QIPIEIYGNKVIGTVLIGPTPVNVIGRNLMTKMGCTLNF

References
Author Title Citation
Rousseau, MN Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. JAIDS, 2000
Gonzales, MJ Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. AIDS, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005