<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MNR13 MNR4705 France 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 10
2 AZT+ DDI 50
3 AZT+ 3TC 40
4 AZT+ 3TC+ IDV 43
5 D4T+ RTV+ SQV 44
6 NVP+ SQV+ NFV+ D4T 5
7 D4T+ 3TC+ NFV+ SQV 2

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, N88S, L90M L33I, Q58E L10V, T12P, I13V, K14R, K20T, M36I, I62V, L63P, A71T, I72T, I93L H69H_NGQCV
>MNR4705| codons 1-99
PQITLWQRPVVPVRIGGQLTEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFIKVREYD
QVPIEICGHKTTGTVLVGPTPVNIIGRSLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69Q_G, L210W, T215Y A62V, K70V Y181C, G190A   T39A, E44D, S68G, V111I, V118I, K122E, I135T, Q174R, D177E, E194K, R199T, H208Y, R211K, K223Q, L228R, K277R, I293V, E297K, M357T, G359S, T386I, A400T, G436E, A437Q, F440L, Y441C E438N, T439F, V442R, D443W, G444A
>MNR4705| codons 1-444
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV
FVIKKKNGQVWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI
CQYMDDLYVASDLKIGQHTTKIEELRQYLWKWGFYTPDKKHQQEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVEQNFLCRWA

References
Author Title Citation
Rousseau, MN Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. JAIDS, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005