Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR12 | MNR4575 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 135 |
| 2 | AZT+ DDI | 20 |
| 3 | 3TC+ IDV+ RTV | 4 |
| 4 | D4T+ 3TC+ IDV | 32 |
| 5 | D4T+ SQV+ RTV | 74 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10I, E35D, M36I, L63P, H69R, V75I |
| >MNR4575| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGRKAIGTILVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V179D | P4S, E28K, K32E, E44D, K49R, D123E, I135T, I178M, T200K, E203D, R211K, A272P, V276I, L283I, V292I, I293V, R356K, A376V, T386I, K395R, E399D, T403L, W410V |
| >MNR4575| codons 1-434 PISSIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELEKDGKISRIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMDI YQYMDDLYVGSDLEIGQHRKKIDELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIVTESIVIWGKIPKFKLPIQRETWDAWWLEYWQATVIPEWEFVNTP PLVKLWYQLEKEPI |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |