Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR11 | MNR4555 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 2 |
| 2 | D4T+ DDI | 30 |
| 3 | DDI+ 3TC+ IDV | 11 |
| 4 | DDI+ 3TC+ SQV+ NFV | 40 |
| 5 | D4T+ NVP+ NFV | 5 |
| 6 | D4T+ EFV+ NFV+ SQV | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | K20I, E35G, M36I, I62V, L63P, A71T |
| >MNR4555| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEGINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTISTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K101P, G190A | V35M, T39K, K43E, V118I, D121H, K122E, K166R, F171Y, Q207E, R211K, A272P, I293V, E297K, I329L, F346G, A360T, K366R, A376T, T386A, I393M, A400T |
| >MNR4555| codons 1-408 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICKELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPYRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPGKNLKTGKYARMRGT HTNDVRQLTEAVQKITTESIVIWGKAPKFKLPMQKETWETWWTEYWQA |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |