Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR10 | MNR4415 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+ DDI | 52 |
| 3 | 3TC+ D4T+ SQV | 17 |
| 4 | 3TC+ D4T+ IDV | 43 |
| 5 | D4T+ DDI+ NFV | 13 |
| 6 | D4T+ DDI+ IDV | 26 |
| 7 | D4T+ SQV+ DDI+ RTV | 30 |
| 8 | AZT+ ABC+ SQV+ NFV | 2 |
| 9 | AZT+ DDI+ SQV+ NFV | 11 |
| 10 | Unknown | 43 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | N83D | L10I, E35D, M36I, N37D, R41K, R57K, I62V, L63P, I64V, A71V, I93L |
| >MNR4415| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDIDLPGKWKPKIIGGIGGFIKVKQYD QVPVEICGHKVIGTVLVGPTPVDVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | T39A, E44D, V118I, D121Y, K122E, I135T, T200I, H208Y, R211K, K219T, I293V, S322T, R356K, M357T, G359S, A376S, T386I, K390R, A400T, T403V |
| >MNR4415| codons 1-439 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELRQYLWKWGFYTPDTKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRSA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWETWWVEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAET |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |