Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR9 | MNR4403 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 20 |
| 2 | AZT+ 3TC | 27 |
| 3 | AZT+ DDI+ IDV | 55 |
| 4 | 3TC+ AZT+ RTV+ SQV+ NVP | 40 |
| 5 | ABC+ EFV+ NFV | 13 |
| 6 | DDI+ ABC+ EFV+ IDV | 5 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | G73S | L10V, I13V, I15V, K20M, E35D, M36I, R41K, K45R, I62V, L63P, I64V |
| >MNR4403| codons 1-98 PQITLWQRPVVTVKVGGQLMEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFVKVRQYD QVPVEICGHKAISTVLVGPTPVNIIGRNLMTQIGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M, M184V, T215F | A62V, V75I, F77L, F116Y, K219Q | K103N | K20R, V35L, V118I, K122E, I135T, A158S, E169D, D177E, I202V, F214L, D218E, Q278H, E291D, I293V, K311R, M357T, R358K, A376T, K390R, E399D, A400T, E404D |
| >MNR4403| codons 1-435 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FVIKKKNSDRWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYYSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPSIFQSSMTKILDPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGTKALTDVVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKITTESIVIWGKTPKFRLPIQKETWDTWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIV |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |