Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR8 | MNR4336 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 41 |
| 2 | 3TC+ D4T | 19 |
| 3 | DDI+ D4T+ IDV | 18 |
| 4 | DDI+ D4T+ RTV | 12 |
| 5 | DDI+ D4T+ NFV | 15 |
| 6 | DDI+ EFV+ NFV | 5 |
| 7 | DDI+ SQV+ NFV | 8 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82A | L10I, L63P, I64L, A71V, T74S, V77I, I93L |
| >MNR4336| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIVGIGGFTKVRQYD QIPLEICGHKVIGSVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | Y181C | V35M, K43E, E44A, V118I, D121H, K122E, S162D, E169D, I178L, T200A, H208Y, R211K, L228H, A272P, K277R, L283I, I293V, R356K, G359S, A371V, K390R, A400T, V435A, K451R |
| >MNR4336| codons 1-460 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILDPFRKQNPDLVI CQYMDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETRLGKAGYVTD |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |