Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR7 | MNR4292 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 100 |
| 2 | AZT+ DDI | 54 |
| 3 | DDC+ AZT | 13 |
| 4 | 3TC+ D4T+ SQV+ RTV | 60 |
| 5 | AZT+ DDI+ IDV | 9 |
| 6 | DDI+ D4T+ 3TC+ RTV | 25 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | V179D | K43Q, E44D, V111I, K122E, D123E, I142V, T165I, I178M, G196E, T200K, Q207A, R211K, A272P, V276I, L283I, A288T, V292I, I293V, T338S, R356K, A360T, T369A, A376I, T386M, K390R, K395R, E399D, T403M, W410V, V435I |
| >MNR4292| codons 1-435 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSVPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDMDI YQYVDDLYVGSDLEIEQHRKKIEELRAHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGTKTLTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWSYQIYQEPFKNLKTGKYAKMRGT HTNDVKQLAEAVQKIITESIVIWGKMPKFRLPIQRETWDAWWMEYWQATVIPEWEFVNTP PLVKLWYQLEKEPII |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | G73S, L89V | L10I, I15V, R41K, D60E, I62V, L63P, A71V, V77I, I93L |
| >MNR4292| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYE QVPIEICGHKVISTVLIGPTPANIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |