Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR5 | MNR4062 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 45 |
| 2 | AZT+ DDI | 82 |
| 3 | DDC+ D4T+ IDV | 60 |
| 4 | 3TC+ RTV+ SQV+ D4T | 27 |
| 5 | AZT+ 3TC+ SQV+ NFV | 16 |
| 6 | DDI+ D4T+ SQV+ NFV | 19 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K20R, K43E, E44A, V60I, K102R, V118I, K122E, D123S, E138A, Q197L, R211K, A272P, E297A, D324E, Q334E, A360T, I375V, A376S, K385R, K390R, A400T, E432G, G436E |
| >MNR4062| codons 1-436 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGLHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEAVQKVSTESIVIWGRTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKGPIVE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73C | L10R, Q18H, N37S, I62V, L63P, I64V, I66V, I72V, V77I, I93L, C95F |
| >MNR4062| codons 1-99 PQITLWQRPRVTIKIGGHLKEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFIKVRQYD QVPVEVCGHKAVCTVLIGPTPVNVIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |