Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR4 | MNR3994 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 40 |
| 2 | RTI | 13 |
| 3 | AZT+ DDI | 20 |
| 4 | AZT+ DDI+ RTV+ SQV | 36 |
| 5 | RTV+ IDV+ AZT+ DDI | 5 |
| 6 | DDI+ D4T+ NFV+ SQV | 36 |
| 7 | 3TC+ AZT+ ABC | 4 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10I, I15V, G16A, K20R, E35D, M36I, N37D, R57K, L63P, A71T, Q92R, I93L |
| >MNR3994| codons 1-99 PQITLWQRPIVTIKVAGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVKQYD QIPIEICGHKTIGTVLVGPTPVNVIGRNLMTRLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K219R | K103N | A98G | E44D, V118I, K122E, D123N, I178M, G196E, E203K, E204D, Q207E, H208Y, R211K, K223Q, A272P, L283I, I326V, Q334L, G359S, A371V, K390R, E399D, A400S, T403M, E449D |
| >MNR3994| codons 1-449 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYIDDLYVGSDLEIEQHRTKIKDLREYLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWDSWWMEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRD |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |