<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MNR2 MNR2 France 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 33
2 AZT+ DDI 46
3 AZT+ DDC 21
4 AZT+ 3TC+ SQV 75
5 3TC+ D4T+ IDV 41
6 D4T+ 3TC+ NFV 16
7 D4T+ NVP+ NFV 9

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54T, V82A   L10I, K20R, E35D, M36I, R41K, L63P, A71V  
>MNR2| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIVGIGGFTKVRQYD
QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, L210W, T215Y K219N V106A   K43E, E44A, V60I, V118I, K122E, I132V, I178M, V179I, I180V, T200A, H208Y, R211K, D218E, V245K, T286A, E297K, D324E, Q334E, R358K, T377N, K390R, K395R, E396D, E399D, A400T  
>MNR2| codons 1-435
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL
DEDFRKYTAFTVPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMIV
YQYMDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMKGA
HTNDVKQLTEAVQKIANESIVIWGKTPKFRLPIQRDTWDTWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIV

References
Author Title Citation
Rousseau, MN Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. JAIDS, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005