Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR2 | MNR2 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 33 |
| 2 | AZT+ DDI | 46 |
| 3 | AZT+ DDC | 21 |
| 4 | AZT+ 3TC+ SQV | 75 |
| 5 | 3TC+ D4T+ IDV | 41 |
| 6 | D4T+ 3TC+ NFV | 16 |
| 7 | D4T+ NVP+ NFV | 9 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, K20R, E35D, M36I, R41K, L63P, A71V |
| >MNR2| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIVGIGGFTKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K219N | V106A | K43E, E44A, V60I, V118I, K122E, I132V, I178M, V179I, I180V, T200A, H208Y, R211K, D218E, V245K, T286A, E297K, D324E, Q334E, R358K, T377N, K390R, K395R, E396D, E399D, A400T |
| >MNR2| codons 1-435 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL DEDFRKYTAFTVPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMIV YQYMDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLTEAVQKIANESIVIWGKTPKFRLPIQRDTWDTWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIV |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |