Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MNR1 | MNR1 | France | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 40 |
| 2 | AZT+ DDI | 17 |
| 3 | AZT+ DDI+ IDV | 54 |
| 4 | D4T+ DDI+ SQV+ RTV | 19 |
| 5 | SQV+ RTV+ D4T+ DDI+ NFV | 15 |
| 6 | 3TC+ D4T+ RTV+ SQV | 3 |
| 7 | 3TC+ RTV+ NFV | 6 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L33I, G73S | L10I, I13V, E35D, M36I, N37D, L63P, A71V, I72L, V77I |
| >MNR1| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVIEDIDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVLSTVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219R | K32N, V35I, E44D, V106I, V118I, K122P, I135K, H208Y, R211K, K277R, T286A, I293V, E297K, Q334E, M357T, T369V, A371V, I375V, A376T, K390R, A400T, Y405H, V435I, A445Q, A446L, N447T, K454R |
| >MNR1| codons 1-457 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DPDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLVEVVQKVTTESIVIWGKTPKFRLPIQKETWETWWTEHWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETFYVDGQLTRETKLGRAGY |
References
| Author | Title | Citation |
| Rousseau, MN | Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |