<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MNR1 MNR1 France 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 40
2 AZT+ DDI 17
3 AZT+ DDI+ IDV 54
4 D4T+ DDI+ SQV+ RTV 19
5 SQV+ RTV+ D4T+ DDI+ NFV 15
6 3TC+ D4T+ RTV+ SQV 3
7 3TC+ RTV+ NFV 6

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90M L33I, G73S L10I, I13V, E35D, M36I, N37D, L63P, A71V, I72L, V77I  
>MNR1| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTVIEDIDLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKVLSTVLIGPTPVNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219R     K32N, V35I, E44D, V106I, V118I, K122P, I135K, H208Y, R211K, K277R, T286A, I293V, E297K, Q334E, M357T, T369V, A371V, I375V, A376T, K390R, A400T, Y405H, V435I, A445Q, A446L, N447T, K454R  
>MNR1| codons 1-457
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALIEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL
DPDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLVEVVQKVTTESIVIWGKTPKFRLPIQKETWETWWTEHWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGQLTRETKLGRAGY

References
Author Title Citation
Rousseau, MN Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy. JAIDS, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005