Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1556 | CA20616 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 109 |
| 2 | AZT+DDC | 14 |
| 3 | DDI | 27 |
| 4 | D4T | 21 |
| 5 | 3TC+AZT | 58 |
| 6 | 3TC+AZT+IDV | 48 |
| 7 | D4T+NFV | 25 |
| 8 | DDC+NFV+RTV+SQV | 16 |
| 9 | 3TC+RTV+SQV | 5 |
| 10 | ABC+EFV+RTV+SQV | 44 |
| 11 | ABC+APV+D4T+RTV | 37 |
| 12 | 3TC+EFV+NVP | 15 |
| 13 | 3TC+EFV+LPV+NVP | 53 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, I54V, I84V, L90M | L10F, V11I, L33LF, G73GS, L89V | T12P, I13V, I15V, L19LP, K20T, E35G, M36I, I62V, L63LP, A71X, P79A |
| >CA20616| codons 1-99 PQITLWQRPFIPVKVGGQPTEALLDTGADDTIFEGINLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKXISTVLVGATPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69A_SX, L74LV, M184MV, L210LW, T215CY | A62AV, D67E | L100LI, K103N | V35VA, K43KE, V60VI, K64KR, R83RK, V90VI, V111VI, K122E, I135T, S162Y, L228LH, V245E, A272P, K277R |
| >CA20226| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALAEICTELEEEGKISKIGPENPYNTPI FVIRKKESAKWRKVVDFRELNKKTQDFWEIQLGIPHPAGIKKNKSVTVLDIGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFCTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |