Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1264 | CA20557 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 17 |
| 2 | 3TC+AZT+SQV | 70 |
| 3 | 3TC+AZT+NFV | 21 |
| 4 | 3TC+D4T+RTV+SQV | 15 |
| 5 | 3TC+D4T+RTV+SQV | 75 |
| 6 | 3TC+D4T+DDI+EFV+RTV+SQV | 17 |
| 7 | 3TC+D4T+DDI+RTV+SQV | 18 |
| 8 | 3TC+D4T+RTV+SQV | 46 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, I84V | K43T | Q7H, L10I, I13V, I15V, K20T, E35D, M36L, N37D, D60E, L63P, I64V, V77I |
| >CA20557| codons 1-99 PQITLWHRPIVTVKVGGQLTEALLDTGADDTVLEDLDLPGRWTPKMIVGIGGFVKVRQYE QIPVEICGHKAIGTVLIGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | V35T, R83K, K122KE, I135V, K166R, Q207E, V245E, A272P, K277R |
| >CA20168| codons 1-281 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCK |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |