Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8033 | CA20550 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC | 34 |
| 2 | D4T | 43 |
| 3 | 3TC+ IDV+ D4T | 43 |
| 4 | None | 30 |
| 5 | 3TC+ RTV+ D4T+ SQV | 34 |
| 6 | D4T+ 3TC | 30 |
| 7 | D4T+ ABC+ RTV+ IDV | 13 |
| 8 | D4T+ 3TC+ IDV+ RTV | 80 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | L10I, L19Q, N37S, R41K, K45R, L63P, A71V, I72V, I85IV, Q92K |
| >CA20550| codons 1-99 PQITLWQRPIVTIKIGGQQKEALLDTGADDTILEEMSLPGKWKPRIIGGIGGFIKVRQYD QIPIEICGHKVVGTVLVGPTPANIVGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V, T215F | K219Q | K122E, I135V, Q207E, V245K |
| >CA20160| codons 1-260 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |