Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1499 | CA20545 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 44 |
| 2 | DDI | 126 |
| 3 | D4T | 52 |
| 4 | 3TC+D4T | 65 |
| 5 | 3TC+D4T+IDV | 58 |
| 6 | D4T+NFV+NVP | 63 |
| 7 | 3TC+D4T+EFV+RTV+SQV | 13 |
| 8 | APV+D4T+EFV+NFV | 30 |
| 9 | APV+D4T+NFV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, I84IV, L90M | L10F, G73S, L89LV | E35D, N37Q, I62V, L63P, A71V, V77I, I93L |
| >CA20545| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEDMQLPGRWKPKIIGGIGGFLKVRQYD QVPIEICGHKVISTVLIGPTPVNVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K103N, Y181C, G190A | K20R, V35M, T39A, K43E, E44D, V118I, D123E, I135IM, D177E, G196E, E203K, Q207E, H208Y, R211K, K223Q, A272P, T286A, E297R |
| >CA20155| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVASDLEIEQHRTKIKELREYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTREAE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |