Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4398 | CA20526 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+DDC | 25 |
| 2 | 3TC+D4T+IDV | 72 |
| 3 | 3TC+D4T+RTV+SQV | 76 |
| 4 | APV+D4T+DDI+NVP+RTV | 38 |
| 5 | ABC+D4T+IDV+RTV | 37 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10I, R41RK, K43KR, I62V, L63P, H69Y, A71T, I72E, V77I, I93L |
| >CA20526| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWRPKMIGGIGGFIKVRQYD QVPIEICGYKTEGTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W | K103N, Y181YC | S68G, K122E, I135IT, S162A, I178M, Q207E, R211K, T215X, E233ED, A272P | V10S |
| >CA20137| codons 1-274 PISPIETVPSKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDMVI CQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFXTPDKKHQKEPPFLWMGYDLHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGI |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |