Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8012 | CA20491 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC+ IDV | 69 |
| 2 | AZT+ 3TC+ NFV | 113 |
| 3 | D4T+ DDI+ RTV+ SQV | 13 |
| 4 | D4T+ DDI+ APV | 59 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54L, L90M | L33F, N88D | L10I, K14R, N37D, K55KR, L63P, A71T, I72T, I93L |
| >CA20491| codons 1-99 PQITLWQRPIVTIRIGGQLKEALLDTGADNTVFEEMDLPGRWKPKMIGGIGGFLRVRQYD QIPIEICGHKTTGTVLVGPTPVNIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | V35I, R83K, V118I, K122E, I135V, T139K, V179VI, T200A, Q207E, R211K, F214L, I244V, V245I, A272P, K277R, L283I, T286P |
| >CA20123| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPVILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGPKALTEVIPLTEEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |