Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3914 | CA20474 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 111 |
| 2 | AZT+DDC | 39 |
| 3 | 3TC+AZT | 31 |
| 4 | 3TC+D4T | 37 |
| 5 | AZT+DDI+NFV | 77 |
| 6 | 3TC+AZT+EFV+NFV | 91 |
| 7 | APV+D4T+DDI | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L33I, T74P | L10LI, R41RK, I62V, L63P, H69HY, A71T, I72V, V77I, I93L |
| >CA20474| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVIEEMNLPGKWKPKIIGGIGGFIKVRQYD QVPIEICGYKTVGPVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, M184MV | D67G | K103KN | A98AG | K64R, I142V, G196E, R211A, F214L, V245M, Q278E |
| >CA20087| codons 1-282 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIRKKGSDRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLAWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKELCKL |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |