Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7982 | CA20462 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | 3TC+AZT+IDV | 17 |
| 3 | 3TC+D4T+RTV+SQV | 82 |
| 4 | EFV+3TC+D4T+RTV+SQV | 56 |
| 5 | EFV+3TC+ABC+D4T+RTV+SQV | 21 |
| 6 | None | 17 |
| 7 | EFV+3TC+ABC+APV+RTV | 19 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L10F, L33LF, N83D | T12S, K20R, E34K, E35D, M36I, R41K, I62V, L63P, A71V | R8Q |
| >CA20462| codons 1-99 PQITLWQQPFVSIKIGGQLREALLDTGADDTVFKDINLPGKWKPKMIGGIGGFLKVRQYD QVPIEICGHKVIGTVLVGPTPVDVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219E | Y188L | T39A, V118I, K122E, I135T, S162C, G196E, L210M, R211RK, F214L, K281R, T286A, P294T, E297R |
| >CA20069| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIEQHRTKIEELRQHLMKWGLTTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTEVITLTRE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |