Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7984 | CA20449 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+DDI | 13 |
| 2 | 3TC+D4T+NFV | 44 |
| 3 | 3TC+D4T+NFV+NVP | 21 |
| 4 | APV+D4T+RTV | 71 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84IV, L90M | K20I, N37S, R57K, I62V, L63P, A71AV, T74S, V77I, V82VI, I93L |
| >CA20449| codons 14-99 KIGGQLIEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFMKVKQYDQVPIEICGHKVIG SVLIGPTPINVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | Y181C | V108I | R83K, K101KR, K122P, D177E, V179I, T200A, R211RK, H221HY, L228LR, D250E, A272P | L260L* |
| >CA20074| codons 1-286 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLRKKKSVTILDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII CQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKYQKEPPFRWMGYELHPDKWT VQPIVLPEKESWTVNDIQK*VGKLNWASQIYPGIKVKQLCKLLRGT |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |