Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1869 | CA20427 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 72 |
| 2 | D4T+DLV+RTV+SQV | 9 |
| 3 | 3TC+AZT+IDV | 56 |
| 4 | D4T+EFV+NFV | 37 |
| 5 | ABC+APV+D4T | 18 |
| 6 | None | 48 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82VA | L24I | L10I, I15V, R41K, L63P, T74TS |
| >CA20427| codons 1-99 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPIEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML | S3SC, E44ED, K49R, R83K, K166R, I167V, V245E, E248D, D250E, A272P, K277R | K281K*, T290Q |
| >CA20033| codons 1-291 PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRVLEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLC*LLRGTKALQE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |