Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5970 | CA20411 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | 3TC+AZT+IDV | NA |
| 3 | 3TC+AZT+NFV | 58 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IL, L90M | I3IV, L10I, E35D, M36I, N37S, I62V, L63P, A71V, T74S, V77I, I93L |
| >CA20411| codons 1-99 PQVTLWQRPIVTIKIGGQLKEALLDTGADDTVLEDISLPGRWKPKMIGGIGGFLKVRQYD QVPIEICGHKVIGSVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | V35X, S68SG, T69N, R83K, A98S, K166R, T200TI, R211K, A272P, K277R, E297K | L289LR, A299AG |
| >CA20019| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALXEICTELEKEGKISKIGPENPYNTPV FAIKKKDGNKWRKLVDFRELNKKTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKARTEVIPLTKEGE L |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |