Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1534 | CA20373 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | AZT+DDC | 170 |
| 3 | AZT | 57 |
| 4 | 3TC+AZT | 17 |
| 5 | 3TC+AZT+IDV | 96 |
| 6 | DLV+NFV+SQV | 21 |
| 7 | D4T+DDI+RTV+SQV | 31 |
| 8 | D4T+DDI+IDV+NFV | 43 |
| 9 | APV+AZT+DDC+EFV+SQV | 40 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73C | L10I, R41RK, D60E, I62V, L63P, I64V, K70R, I72E, V77I, I93L |
| >CA20373| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYE QVPVEICGHRAECTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103N, Y181C, G190A | A98G | T39N, K43E, V118I, K122P, D177E, V179T, E203K, Q207E, H208Y, R211K, L228Q, Q278H, T286A, E291D, V292I, I293V |
| >CA19979| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICNELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEITI CQYMDDLYVASDLEIGQHRTKIKELREYLWKWGFYTPDKKHQKEPPFQWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTDIVPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive value of HIV-1 genotypic resistance test interpretation algorithms. | J Infect Dis, 2009 |